Epigenome-wide association study of short-term temperature fluctuations based on within-sibship analyses in Australian females

Y Wu; R Xu; S Li; E Ming Wong; MC Southey; JL Hopper; MJ Abramson; S Li; Y Guo

Journal article

Epigenome-wide association study of short-term temperature fluctuations based on within-sibship analyses in Australian females

Y Wu, R Xu, S Li, E Ming Wong, MC Southey, JL Hopper, MJ Abramson, S Li, Y Guo

Environment International | Published : 2023

DOI: 10.1016/j.envint.2022.107655

Open access

Abstract

Background: Temperature fluctuations can affect human health independent of the effect of mean temperature. However, no study has evaluated whether short-term temperature fluctuations could affect DNA methylation. Methods: Peripheral blood DNA methylation for 479 female siblings of 130 families were analysed. Gridded daily temperatures data were obtained, linked to each participant's home address, and used to calculate nine different metrics of short-term temperature fluctuations: temperature variabilities (TVs) within the day of blood draw and preceding one to seven days (TV 0–1 to TV 0–7), diurnal temperature range (DTR), and temperature change between neighbouring days (TCN). Within-sibsh..

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University of Melbourne Researchers

Melissa Southey Author

Shuai Li Author

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Grants

Awarded by Boehringer Ingelheim

Funding Acknowledgements

YW and RX are supported by China Scholarship Council (202006010044 and 201806010405). SSL is supported by an Emerging Leader Fellowship of the Australian National Health and Medical Research Council (NHMRC; GNT2009866). SL is supported by an Early Career Research Fellowship of the Victorian Cancer Agency (ECRF 19020). YG is supported by NHMRC Career Development Fellowship (GNT1163693) and Leader Fellowship (GNT2008813). MCS is supported by a NHMRC Senior Research Fellowship (APP1155163) . JLH is supported by a NHMRC Senior Principal Research Fellowship. The Australian Mammographic Density Twins and Sisters Study (AMDTSS) was facilitated through access to Twins Research Australia, a national resource supported by a Centre of Research Excellence Grant (1079102 and 1050561) from the NHMRC and the Cancer Australia and National Breast Cancer Foundation (509307). The funding bodies did not play any role in the study design, data collection, data analyses, results interpretation, and writing of this manuscript.